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GLP-1Rs are also present on Schwann cells and sensory, motor, and enteric neurons, implicating them in peripheral neuropathy and metabolic disease modulation [73]

This initial phase is critical for laying the groundwork for a more secure and resilient domestic supply chain, aligning with national pharmaceutical security goals

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Preclinical studies have explored possible mechanisms including improved endothelial function, reduced inflammation, and potential anti-atherosclerotic properties, though these effects require further investigation in humans before definitive conclusions can be drawn